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KMID : 0616120070380040400
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Korean Journal of Pharmacognosy
2007 Volume.38 No. 4 p.400 ~ p.402
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Hepatoprotective compounds of Cassiae Semen on tacrine-induced cytotoxicity in Hep G2 cells
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Byun Erisa
Yoon Kwon-Ha
Kim Youn-Chul
Li Bin
Lee Dong-Sung
Jeong Gil-Saeng
An Ren-Bo
Ko Eun-Kyung
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Abstract
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Tacrine is an acetylcholinesterase inhibitor that is approved for the treatment of Alzheimer’s disease. However, tacrine treatment for Alzheimer’s disease results in reversible hepatotoxicity in 30-50% of patients, which seriously limits its clinical use. Accordingly, the identification of constituents in natural products that have protective effects on tacrine-induced hepatotoxicity would be valuable. In the present study, an immortalized human hepatoma cell line, HepG2 was employed to screen for agents that protect against tacrine-induced hepatotoxicity. The bioassay-guided fractionation of water extract of Cassiae Semen furnished two anthraquinones, aurantio-obtusin (1) and obtusifolin (2). Compounds 1 and 2 showed hepatoprotective effects with the protection ratio values of 55.3 +/? 0.5% and 41.2 +/? 0.8% at 160 μM, respectively.
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KEYWORD
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Cassia obtusifolia L, aurantio-obtusin, obtusifolin, tacrine, hepatoprotection, HepG2
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